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KMID : 0606920160240060616
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Biomolecules & Therapeutics
2016 Volume.24 No. 6 p.616 ~ p.622
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Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress
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Oh Min-Chang
Piao Mei Jing
Fernando Pattage Madushan Dilhara Jayatissa
Han Xia
Hewage Susara Ruwan Kumara Madduma
Park Jeong-Eon
Ko Mi-Sung
Jung U-Hee
Kim In-Gyu
Hyun Jin-Won
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Abstract
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Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.
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KEYWORD
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Baicalein, Ultraviolet B, Oxidative stress, Reactive oxygen species, HaCaT cells
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